A Hybrid SDN-based Architecture for Wireless Networks

With new possibilities brought by the Internet of Things (IoT) and edge computing, the traffic demand of wireless networks increases dramatically. A more sophisticated network management framework is required to handle the flow routing and resource allocation for different users and services. By separating the network control and data planes, Software-defined Networking (SDN) brings flexible and programmable network control, which is considered as an appropriate solution in this scenario.Although SDN has been applied in traditional networks such as data centers with great successes, several unique challenges exist in the wireless environment. Compared with wired networks, wireless links have limited capacity. The high mobility of IoT and edge devices also leads to network topology changes and unstable link qualities. Such factors restrain the scalability and robustness of an SDN control plane. In addition, the coexistence of heterogeneous wireless and IoT protocols with distinct representations of network resources making it difficult to process traffic with state-of-the-art SDN standards such as OpenFlow. In this dissertation, we design a novel architecture for the wireless network management. We propose multiple techniques to better adopt SDN to relevant scenarios. First, while maintaining the centralized control plane logically, we deploy multiple SDN controller instances to ensure their scalability and robustness. We propose algorithms to determine the controllers\u27 locations and synchronization rates that minimize the communication costs. Then, we consider handling heterogeneous protocols in Radio Access Networks (RANs). We design a network slicing orchestrator enabling allocating resources across different RANs controlled by SDN, including LTE and Wi-Fi. Finally, we combine the centralized controller with local intelligence, including deploying another SDN control plane in edge devices locally, and offloading network functions to a programmable data plane. In all these approaches, we evaluate our solutions with both large-scale emulations and prototypes implemented in real devices, demonstrating the improvements in multiple performance metrics compared with state-of-the-art methods

Exploration on Innovation in Planning and Design of Pastoral Complex

Based on the background and development of the pastoral complex, it is believed that the pastoral complex is an inevitable trend of the development of modern agriculture and it is the product of agriculture developing to a higher stage following agricultural industrial park, beautiful countryside, characteristic town, and whole area tourism. Combined with many years of planning and design practice of Wuhan Modern Urban Agriculture Planning and Design Institute, this paper summarized ideas of construction and operation of the pastoral complex, and discussed the construction of pastoral complex planning system, in the hope of providing certain reference for planning of pastoral complex in the whole country in the new period. Finally, through the overview of development history and highlight of urban agriculture in Wuhan, it came up with measures and recommendations for development of pastoral complex in Wuhan City

The protective effects of electroacupuncture on intestinal barrier lesions in IBS and UC model

Abstract Irritable bowel syndrome (IBS) and ulcerative colitis (UC) are two intestinal diseases with different pathological changes. Electroacupuncture (EA) at Zusanli (ST36) on both IBS and UC is widely used in clinic practice. But it is unclear whether acupuncture at one acupoint can treat two different intestinal diseases at different layers of intestinal barrier. To address this question, we explored three intestinal barrier lesions in IBS and UC mice with the aid of transcriptome data analysis and studied the efficacy of EA at ST36 on them. The transcriptome data analysis showed that both UC and IBS had disrupted intestinal barrier in various layers. And both UC and IBS had epithelial barrier lesions with reduction of ZO-1, Occludin and Claudin-1, while UC rather than IBS had the destruction of the mucus barrier with less MUC2 expression. As to the vascular barrier, UC showed a higher CD31 level and mesenteric blood flow reduction, while IBS showed a lower PV-1 level. EA at ST36 can significantly improve the above lesions of intestinal barrier of IBS and UC. Our results gave more details about the comprehensive protective effect of EA for UC and IBS. We guess the effect of acupuncture may be a kind of homeostasis regulation

Ultrasound-Responsive Biomimetic Superhydrophobic Drug-Loaded Mesoporous Silica Nanoparticles for Treating Prostate Tumor

Interfacial nanobubbles on a superhydrophobic surface can serve as ultrasound cavitation nuclei for continuously promoting sonodynamic therapy, but their poor dispersibility in blood has limited their biomedical application. In this study, we proposed ultrasound-responsive biomimetic superhydrophobic mesoporous silica nanoparticles, modified with red blood cell membrane and loaded with doxorubicin (DOX) (F-MSN-DOX@RBC), for RM-1 tumor sonodynamic therapy. Their mean size and zeta potentials were 232 ± 78.8 nm and −35.57 ± 0.74 mV, respectively. The F-MSN-DOX@RBC accumulation in a tumor was significantly higher than in the control group, and the spleen uptake of F-MSN-DOX@RBC was significantly reduced in comparison to that of the F-MSN-DOX group. Moreover, the cavitation caused by a single dose of F-MSN-DOX@RBC combined with multiple ultrasounds provided continuous sonodynamic therapy. The tumor inhibition rates in the experimental group were 71.5 8 ± 9.54%, which is significantly better than the control group. DHE and CD31 fluorescence staining was used to assess the reactive oxygen species (ROS) generated and the broken tumor vascular system induced by ultrasound. Finally, we can conclude that the combination of anti-vascular therapy, sonodynamic therapy by ROS, and chemotherapy promoted tumor treatment efficacy. The use of red blood cell membrane-modified superhydrophobic silica nanoparticles is a promising strategy in designing ultrasound-responsive nanoparticles to promote drug-release